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Observation 159

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Species Saccharomyces cerevisiae
Strain W303AR5
Mating Type mata
Temperature 30
Lifespan 11
Reference Lifespan 22
Lifespan Change -50%
Lifespan Measure
Lifespan Effect decreased
Significance significant
Citation Imai S, Armstrong CM, Kaeberlein M, Guarente L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.. Nature 403: 795-800. [pubmed]
Details
Deletion of SIR2 shortened life span. The HML deletion in this haploid strain prevents co-expression of both mating types.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SIR2 deletion / null
HML deletion / null