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Observation 153

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Species Drosophila melanogaster
Strain Canton-S, cn bw
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Simon AF, Shih C, Mack A, Benzer S. (2003). Steroid control of longevity in Drosophila melanogaster. Science 299: 1407-10. [pubmed]

Flies heterozygous for mutant alleles of EcR live approximately 45% longer (mean life-span) than wild-type flies.

Other phenotypes: Homozygous mutantion of EcR is inviable. Development time and weight of EcR +/- flies was the same as control animals, however resistance to temperature, oxidative stress, and starvation was increased in the heterozygotes [pubmed]. Mutation of DTS-3, a gene involved in ecdysone biosynthesis has a similar effect on longevity in female flies [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
EcR non-null recessive 35540 View