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Observation 145

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Species Drosophila melanogaster
Strain PdL x rtTA; Oregon-R x rtTA
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Landis GN, Bhole D, Tower J. (2003). A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, . Genome Biol. [pubmed]

Overexpression of filamin from a doxycycline-inducible promoter results in a 7-9% increase in mean life-span.

Other phenotypes: Filamin is involved in cytokinesis and ring canal formation [pubmed][pubmed]. Drosophila filamin binds to both Drosophila and human presenilins, and filamin interacts genetically with presenilin in Drosophila [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
cher over-expression 42066 View