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Observation 144

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Species Drosophila melanogaster
Strain PdL x rtTA; Oregon-R x rtTA
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Landis GN, Bhole D, Tower J. (2003). A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, . Genome Biol. [pubmed]
Details

Overexpression of fwd from a doxycycline-inducible promoter results in a 7-9% increase in mean life-span.

Other phenotypes: Fwd regulates actin organization and ring canal formation during germline cytokinesis [pubmed]. Fwd catalyzes the first step in the synthesis of the key regulatory membrane phospholipid PIP2,which is generated from PIP by a PI 4,5-kinase.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Fwd over-expression