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Observation 143

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Species Drosophila melanogaster
Strain PdL x rtTA; Oregon-R x rtTA
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Landis GN, Bhole D, Tower J. (2003). A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, . Genome Biol. [pubmed]
Details

Overexpression of rdh from a doxycycline-inducible promoter results in a 6-8% increase in mean life-span.

Other phenotypes: Cct1 catalyzes the conversion of phosphocholine to CDP-choline and is the rate-limiting enzyme in the phosphatidylcholine biosynthetic pathway [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Cct1 over-expression 117353 View