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Observation 135

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Species Mus musculus
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation . (2003). Extended longevity in mice lacking the insulin receptor in adipose tissue.. Science 299: 572-4. [pubmed]

Adipocyte-specific disruption of the insulin receptor results in a 15-18% increase in mean, median, and maximum life-span.

Other phenotypes: Life-span extension is observed in both male and female fat-specific insulin receptor knock-out (FIRKO) animals. FIRKO mice consume the same amount of food on a per animal basis as control mice, but have 15-25% lower body mass and 50-70% reduced fat mass. Mutation of the insulin receptor extends life-span up to 85% in female flies [pubmed]. In mice, disruption of InsR in all tissues results in neo-natal lethality [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Insr deletion / null 16337 View