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Observation 123

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Species Saccharomyces cerevisiae
Strain PSY316
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect decreased
Significance significant
Citation Kaeberlein M, Andalis AA, Fink GR, Guarente L. (2002). High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction.. Mol. Cell. Biol. 22: 8056-66. [pubmed]
Details

Deletion of GPD1 shortens life-span by 25% and prevents life-span extension by high osmolarity.

Other phenotypes: Transcriptional regulation of GPD1 by osmotic stress requires HOG1 [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
GPD1 deletion / null 851539 View