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Observation 122

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Species Saccharomyces cerevisiae
Strain PSY316
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect decreased
Significance significant
Citation Kaeberlein M, Guarente L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity.. Genetics 160: 83-95. [pubmed]
Details

Deletion of HOG1 shortens life span by 25% and prevents life-span extension by high osmolarity.

Other phenotypes: HOG1 is required for many of the transcriptional responses to high osmolarity, including increased glycerol biosynthesis and MSN2/MSN4-dependent stress response [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
HOG1 deletion / null 850803 View