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Observation 121

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Species Saccharomyces cerevisiae
Strain DBY746
Temperature 30
Lifespan
Reference Lifespan
Lifespan Change 90%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD. (2001). Regulation of longevity and stress resistance by Sch9 in yeast.. Science 292: 288-90. [pubmed]
Details

A transposon mutagenized allele of CYR1 results in a 90% increase in chronological life-span.

Other phenotypes: Null mutant arrest at G1 phase is rescued by exogenous cAMP [pubmed]. A transposon mutagenized allele of CYR1 results in resistance to hydrogen peroxide, and resistance to heat shock [pubmed]. Deletion of SOD2 fails to prevent the increased stationary phase survival caused by mutation of CYR1 [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
CYR1 mTn non-null recessive 853452 View