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Observation 120

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Species Saccharomyces cerevisiae
Strain SP-4
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect none
Significance
Citation Kirchman PA, Kim S, Lai CY, Jazwinski SM. (1999). Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae.. Genetics 152: 179-90. [pubmed]
Details

Overexpression of SOD1 has no effect on replicative life-span.

Other phenotypes: Deletion of Cu-Zn superoxide dismutase decreases replicative life-span by approximately 40% [pubmed]. The magnitude of the decrease in life-span does not appear to be dependent on oxygen concentration in the atmosphere [pubmed]. Deletion of SOD1 shortens chronological life-span as well as replicative life span [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SOD1 over-expression 853568 View