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Observation 112

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Species Mus musculus
Strain 129Ola and BalbC
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ. (2000). Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.. Endocrinology 141: 2608-13. [pubmed]

Mice homozygous for disruption of GHR/BP have a life-span that is 40-50% longer than wild type or heterozygous mice.

Other phenotypes: The GHR/BP knockout mouse is a model for the rare human disease Laron syndrome [pubmed]. Serum levels of GH are elevated in mutant mice [pubmed]. Mutant mice are smaller than wild type mice. IGF-I and IGFBP-3 levels are also reduc

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
GHR deletion / null