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Observation 107

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Species Drosophila melanogaster
Strain
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.. Science 292: 104-6. [pubmed]
Details

Mutation of chico results in life-span extension of up to 36% in heterozygous females.

Other phenotypes: Mutation of chico results in life-span extension of up to 48% in homozygous recessive female animals. Male heterozygotes live 13% longer than wild type, but male homozygous recessive animals have a shortened life-span [pubmed] Chico heterozygous females have reduced fecundity and homozygous recessive animals are sterile. Chico heterozygotes are resistant to starvation but not oxidative or temperature stress [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
chico non-null recessive 64880 View