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Observation 1040

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Species Saccharomyces cerevisiae
Strain PSY316AT
Mating Type matalpha
Temperature 30
Lifespan 22.7 divisions
Reference Lifespan 23.3 divisions
Lifespan Change -2.58%
Lifespan Measure mean
Lifespan Effect decreased
Significance not significant
Citation Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Ke. (2005). Substrate-specific activation of sirtuins by resveratrol.. J. Biol. Chem. 280: 17038-45. [pubmed]
Integration of a second copy of SIR2 failed to significantly alter life span in the PSY316 strain background. This differs from the increased life span observed for SIR2-overexpression in wth W303 and BY4742 strain backgrounds.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SIR2 over-expression