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Observation 1039

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Species Homo sapiens
Strain SGC-7901
Sex diploid
Cell Type gastric cancer
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure median
Lifespan Effect decreased
Significance significant
Citation Zhang XW, Zhang L, Qin W, Yao XH, Zheng LZ, Liu X, Li J, Guo WJ. (2010). Oncogenic role of the chromobox protein CBX7 in gastric cancer. 29: 114. [pubmed]
Details

Knockdown of CBX7 expression in gastric cancer cells led to increased cellular senescence, decreased cellular proliferation and migration ability, accompanied by upregulation of p16(INK4a). CBX7 may act as an oncogene in gastric cancer, and regulate tumorigenesis, cell migration and cancer metastasis partially via p16(INK4a) regulatory pathway.

Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating expression of the INK4a/ARF tumor suppressor locus.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
CBX7 RNAi knockdown