> Tools

Observation 1036

Related Observations
User Comments

Please login to leave comments.

Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 25.3 days
Reference Lifespan 24.4 days
Lifespan Change 3.69%
Lifespan Measure mean
Lifespan Effect increased
Significance not significant
Citation Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. (2009). Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-8. [pubmed]
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
hif-1 RNAi knockdown
rrf-3 pk1426 loss of function
vhl-1 RNAi knockdown