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Observation 1036

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 25.3 days
Reference Lifespan 24.4 days
Lifespan Change 3.69%
Lifespan Measure mean
Lifespan Effect increased
Significance not significant
Citation Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. (2009). Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-8. [pubmed]
Details
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
hif-1 RNAi knockdown
rrf-3 pk1426 loss of function
vhl-1 RNAi knockdown