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Observation 103

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Species Saccharomyces cerevisiae
Strain W303R
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect decreased
Significance significant
Citation Kaeberlein M, Guarente L. (2002). Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity.. Genetics 160: 83-95. [pubmed]
Details

Deletion of SWI4 shortens life-span by approximately 90%.

Other phenotypes: SSD1-V partially suppresses the short life-span of a swi4 mutant. Mutation of swi4 results in slow growth and temperature sensitivity, both of which are suppressed by SSD1-V.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SWI4 deletion / null 856847 View