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Observation 1026

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 28.2 days
Reference Lifespan 21.7 days
Lifespan Change 29.95%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. (2009). Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-8. [pubmed]
RNAi knock-down of daf-2 significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that insulin-like signaling acts in a longevity pathway parallel to VHL-1/HIF-1.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
hif-1 ia04 deletion / null
vhl-1 ok161 deletion / null

Environment Interventions

Type Body
Dietary restriction Bacterial deprivation