Sageweb.org > Tools

Observation 1026

Export: CSV XML YAML
Related Observations
User Comments

Please login to leave comments.

Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 28.2 days
Reference Lifespan 21.7 days
Lifespan Change 29.95%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. (2009). Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-8. [pubmed]
Details
RNAi knock-down of daf-2 significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that insulin-like signaling acts in a longevity pathway parallel to VHL-1/HIF-1.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
hif-1 ia04 deletion / null
vhl-1 ok161 deletion / null

Environment Interventions

Type Body
Dietary restriction Bacterial deprivation