> Tools

Observation 1022

Related Observations
User Comments

Please login to leave comments.

Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 24.8 days
Reference Lifespan 24.5 days
Lifespan Change 1.22%
Lifespan Measure mean
Lifespan Effect increased
Significance not significant
Citation Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. (2009). Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-8. [pubmed]
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
hif-1 ia04 deletion / null
vhl-1 ok161 deletion / null