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Observation 1015

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 25.7 days
Reference Lifespan 19.6 days
Lifespan Change 31.12%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. (2009). Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-8. [pubmed]
RNAi knock-down of daf-16 failed to prevent life span extension from deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
daf-16 RNAi knockdown
vhl-1 ok161 deletion / null