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Observation 1013

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 41.5 days
Reference Lifespan 24.1 days
Lifespan Change 72.2%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. (2009). Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-8. [pubmed]
Deletion of vhl-1 increased life span additively with dietary restriction by bacterial deprivation. These data support the model that VHL-1 and dietary restriction act in parallel pathways to promote longevity.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
vhl-1 ok161 deletion / null

Environment Interventions

Type Body
Dietary restriction Bacterial deprivation