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Observation 1012

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 29.8 days
Reference Lifespan 23.2 days
Lifespan Change 28.45%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. (2009). Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-8. [pubmed]
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
vhl-1 ok161 deletion / null