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Observation 1

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Species Saccharomyces cerevisiae
Strain W303-1A
Mating Type mata
Temperature 30
Lifespan 3.3 divisions
Reference Lifespan 24.5 divisions
Lifespan Change -86.53%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Sinclair DA, Mills K, Guarente L. (1997). Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.. Science 277: 1313-6. [pubmed]

Deletion of ADA1 shortens life-span by approximately 80%.

Other phenotypes: This unlikely to be a premature aging phenotype as old ADA1 cells do not become prematurely sterile or show other biomarkers of yeast aging [pubmed] [pubmed]. ADA1 mutants are temperature-sensitive and respiratory-deficient [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
ADA1 deletion / null